Find Ketamine Therapy Near You
Browse 1160+ ketamine therapy providers across the United States
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About Ketamine Therapy
Ketamine therapy is an emerging treatment showing remarkable results for treatment-resistant depression, anxiety, PTSD, chronic pain, and other conditions. Originally developed as an anesthetic in the 1960s, ketamine has been found to rapidly reduce symptoms in patients who have not responded to traditional treatments, often within hours rather than weeks.
How Ketamine Therapy Works
Ketamine works differently from conventional antidepressants. Rather than targeting serotonin or norepinephrine, it blocks NMDA receptors in the brain and promotes the release of glutamate, which triggers a cascade that strengthens and restores neural connections — a process known as neuroplasticity. This mechanism is believed to explain why ketamine can produce rapid antidepressant effects where other medications have failed.
FDA-Approved vs. Off-Label Use
In 2019, the FDA approved Spravato (esketamine) nasal spray for treatment-resistant depression and, later, for adults with major depressive disorder with acute suicidal ideation or behavior. Spravato must be administered in a certified healthcare setting under medical supervision. IV ketamine infusions, IM injections, and oral ketamine are used off-label for psychiatric conditions — meaning the FDA has not specifically approved ketamine for these uses, though the underlying drug has decades of clinical history and a growing body of research supporting its effectiveness.
Conditions Treated
Ketamine therapy is most commonly used for treatment-resistant depression, but providers also treat anxiety disorders, PTSD, OCD, bipolar depression, chronic pain syndromes, and complex regional pain syndrome (CRPS). The specific conditions a clinic treats depend on the provider's training, the treatment modality offered, and the clinical evidence they follow.
How to Choose a Provider
When evaluating ketamine therapy providers, look for clinics staffed by board-certified physicians (psychiatrists, anesthesiologists, or pain specialists), clear protocols for screening and monitoring, transparent pricing, and a willingness to coordinate with your existing care team. The American Society of Ketamine Physicians (ASKP3) publishes clinical standards that reputable providers follow. Ask about the provider's experience, what monitoring occurs during treatment, and what follow-up care is included.
This directory brings together 1160+ providers across 7 practice types who offer various forms of ketamine treatment, including IV infusions, nasal spray (Spravato), sublingual tablets, and at-home programs.
Editorial standards: Directory content is compiled from provider websites, professional organizations, and verified medical directories. Health information on this page references peer-reviewed research, NIMH, and FDA publications. Read our full editorial policy.
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